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The principle of antibacterial properties of nanosilver materials
- May 08, 2018 -

(1) Change cell membrane permeability. Treatment of bacteria with nanosilver can change the permeability of the cell membrane, resulting in the loss of many nutrients and metabolites, and eventually causing cell death;
(2) DNA damage. Nanosilver can release silver ions. The released silver ions can damage the DNA molecules and some proteases of cells, resulting in cross-linking of DNA molecules, or catalyzing the formation of free radicals, which results in denaturation of viral proteins while inhibiting DNA molecules. On the electron donor, breaking the DNA strand and causing the cell to die;
(3) Decrease dehydrogenase activity. Nano-silver particles can interact with many groups in cellular proteins, such as sulfhydryl groups, amino groups, etc., thereby reducing the activity of these groups. After treatment with nano-silver, E. coli can significantly reduce the activity of dehydrogenase in the respiratory chain. The enzyme activity decreased with increasing nano-silver concentration;
(4) Oxidative stress. Nano-silver induces ROS generation in the cells, further reducing the amount of reduced coenzyme II (NADPH) oxidase inhibitors (DPI), leading to cell death.

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